The Kansas Highway Patrol reported a 2004 Ford F150 driven by Tyler Loyd Loomis, 25, McPherson, was northbound on Interstate 135 three miles northeast of Moundridge.
The pickup left the roadway, traveled through the median crossing into the path of a southbound 2015 Peterbilt semi, then struck a guardrail.
Loomis was pronounced dead at the scene.
The semi driver Alan Henry Feicht, 57, Sioux Falls, South Dakota, was possibly injured. The KHP did not report where he was treated. Loomis was not wearing a seat belt, according to the KHP.